The skin consists of two layers: the epidermis, which is the thin outer layer, and the dermis, the deeper layer beneath. The pathology of a keloid originates in the dermis, where there is an excessive accumulation of densely packed collagen fibers that are oriented haphazardly in multiple directions.
Keloid Tissue under microscope - Low magnification.
The dark layer on top represents the epidermis, while the pink layer beneath is the dermis. This dermal layer is infiltrated with collagen and contains fibroblasts, which are the cells responsible for producing collagen.
Keloid Tissue under microscope - high magnification.
Much of the pink tissue is composed of disorganized keloidal collagen fibers. The blue spots represent the nuclei of the cells present in the keloid tissue, primarily fibroblasts, along with lymphocytes (a type of blood cell).
