Pathology of Keloid

When we look at keloids under microscope, we notice that the top levels of skin, what is known as epidermis, is relatively normal and deep parts of the skin, where the keloid tissue resides, is mostly made of excessive amounts of tightly packed collagen fibers randomly oriented in irregular sheets.

Keloid Pathology

Keloid Tissue under microscope

Keloid tissue under microscope, showing dense collagen bundles in red and collagen forming and other cells in blue.

Collagen is produced by specialized cells, known as fibroblasts.